Chasing a target of 183 runs, LSG were bowled out for 101.
Akash Madhwal picked up a fifer by conceding only five runs.
Earlier, Mumbai scored 182/8 after opting to bat first.
Cameron Green was Mumbai's leading run-scorer, with his 23-ball 41.
LSG vs MI Live Score: Mumbai Dream Still Alive
Mumbai Indians have produced a magnificent show when the stakes were highest, whilst from Lucknow Super Giants, it was complete capitulation after what seemed to be a good start.
Akash Madhwal has scripted history here, by dismissing Mohsin Khan in the 17th over. The pacer has conceded just five runs and has picked up as many wickets.
Chasing a target of 183 runs, Lucknow are bowled out for 101. Certainly, not the way they would have wanted their campaign to conclude, but at the other end of the spectrum, Mumbai's dream of winning the sixth IPL title is still alive. Very much alive.
LSG vs MI Live Score: Collapse Continues
Nothing but a collapse from Lucknow Super Giants!
Two more wickets in the 14th over. Ravi Bishnoi is first caught at long-on, and then, another run out. As destiny would have, Deepak Hooda is the victim this time around, after being left unscathed in the previous occasions.
MI are 100/9.
LSG vs MI Live Score: Advantage MI
Look away Lucknow fans!
This is the absolute last thing LSG fans would have wanted to see at this stage – two run outs in the same over. Firstly, Marcus Stoinis collided with Deepak Hooda to throw his wicket away. Moments later, a mix-up between Krishnappa Gowthan and Hooda resulted in the former's wicket. Disaster. Total disaster.
LSG are 94/7 after 13 overs.
LSG vs MI Live Score: Positive Start From Hooda
Deepak Hooda has had a season to forget, but he needs to produce the goods for his team now, being the last recognised batter in the lineup. The all-rounder has started well, striking a six off Piyush Chawla's bowling.
LSG are 86/5 after 11 overs.