How does the vaccine work?

It is a recombinant protein-based COVID-19 vaccine, which means it is a vaccine produced using a viral particle with the aid of recombinant technology. Here, Sanofi provides its recombinant antigen or the anti-viral particle. Meanwhile, GSK contributes its pandemic adjuvant or the agent that stabilises it. The adjuvant enhances the immune response to the vaccine, thereby increasing the efficacy too. This technology has been used and proven successful against influenza earlier. Meanwhile, in addition to the adjuvant recombinant protein-based vaccine in collaboration with GSK, Sanofi is developing a messenger RNA vaccine in partnership with Translate Bio.

What are the advantages of the technology used?

The technology is designed to offer the advantages of stability at temperatures used for routine vaccines. This makes it easily implementable and easier to distribute at a global scale through existing infrastructures where vaccines are stored at normal refrigerator temperature, the companies said. It also offers the potential to generate high and sustained immune responses, and the potential to prevent virus transmission, the statement added.

What Stage Is the Trial In?

The experimental vaccine is in the Phase 2 trial. The companies said the Phase 2 interim results show that the vaccine candidate triggered strong immune response amongst adults of all age groups with 95 percent to 100 percent seroconversion rates or production of antibodies.

How is it different from Covaxin and Covishield?

Covishield or the Oxford-AstraZeneca vaccine which is being manufactured by the Serum Institute (SII) is a viral vector vaccine. Meanwhile, Covaxin , the indigenous vaccine by Bharat Biotech in collaboration with the Indian Council of Medical Research (ICMR) is an inactivated COVID-19 vaccine. Covishield has an efficacy of 62-90 percent while the clinical efficacy of Covaxin was found to be 78 per cent in the interim data of the phase 3 clinical trial. Full data of phase 3 has still not been released by Bharat Biotech. (This was first published on FIT and has been republished with permission.)

ADVERTISEMENTREMOVE AD

Members Only

How Does Sanofi-GSK’s New COVID Vaccine Work? What’s Different?

The experimental vaccine is in the Phase 2 trial. Here’s what you need to know about it.

FIT

Updated: 19 May 2021, 10:33 AM IST

F.A.Q

Small

Medium

Large

French pharma giant Sanofi and UK's GlaxoSmithKline Plc (GSK) reported on Monday, 17 May, that the clinical trials of their COVID-19 vaccine showed strong immune response, as the world races to deliver vaccines to help end the pandemic.

The vaccine candidate “achieved strong rates of neutralising antibody responses, in line with those measured in people who have recovered from COVID-19, in all adult age groups in a Phase 2 study with 722 volunteers," the companies said in a statement.

Read Latest News and Breaking News at The Quint, browse for more from coronavirus and faq

Topics: Sanofi Pharma COVID-19 COVID-19 FAQ

Published: 18 May 2021, 1:41 PM IST