COVID-19: Has Industrial Oxygen Spurred Record Black Fungus Cases?

From less than 100 cases a year, India has reported about 10,000 cases of the deadly mucormycosis, or 'black fungus', in just a few months amid the massive second wave of the COVID-19 pandemic.Doctors and health experts are on a hunt to find out what could be driving the unprecedented surge in black fungus cases.From steroid and iron theories to mask and zinc theories, the medical fraternity is exploring all the factors that could have triggered the infections, not just in COVID patients but also in those who have recovered from the disease.Is there a correlation between the quality of the industrial oxygen used and the spike in the otherwise rare infection? We speak with experts.FAQ: What Is ‘Black Fungus’ in COVID Patients? How Lethal Is It?Is There a Missing Link?Diabetes and indiscriminate use of steroids as well as immunosuppression due to the COVID virus still continue to be the major factors which the doctors agree upon. However, is there a missing link that would explain the unusual rise in cases of 'black fungus' infections the country is witnessing?Dr Sampath Chandra Prasad Rao, a skull surgeon at Bengaluru’s Manipal Hospital says, we need to look at it from an epidemic point of view. Dr Rao is one of the leading members of a team of medical experts, examining the source of contamination and providing SOPs to the Karnataka government.There has been a delay in declaring this an epidemic and making it a notifiable disease, Mr Rao said.Mucormycosis was declared an epidemic on 20 May.When an epidemic is declared, one of the first things that is done is to trace the possible source of contamination.Amid Shortage, Govt Allows 5 More Firms to Make Black Fungus Drug“When there is a source, which is bearing in on an immunocompromised population like in India, with COVID, with everything that the scientific community has agreed upon, then we have a huge crisis like we’re having now. That is when 10,000 cases can be seen.”Dr Sampath Chandra Prasad Rao, skull surgeon, Manipal Hospital, BengaluruMr Rao said there are multiple factors like steam inhalation, in-house contamination, waste disposal, among others that could be influencing the fungal colonisation at home.What about the use of industrial units to supply medical grade oxygen?"If you look at the timeline, the huge surge in cases happened just about the time after the industrial units were put into oxygen production," Dr Rao said, adding that there is a big reason to believe that this could be a contributing factor.Demand-Supply Gap of Black Fungus Drug ‘Too Wide to Bridge’: HCQuality of Medical Oxygen, Cylinders, and PipelinesAs demand overshot supply of oxygen, the centre directed industrial units to divert liquid oxygen for medical use. While the move helped bridge the oxygen gap, there is no guarantee the SOPs were followed to maintain the hygiene of the medical grade oxygen, Dr Rao said."Unknowingly perhaps, have we let an alien into the medical system?"“There is a long process with multiple steps between production of liquid oxygen to the delivery of liquid oxygen cylinders to hospitals. So, in this process, are SOPs being followed?” he asked.The oxygen cylinders are also a huge source of contamination when sterilisation techniques are not followed. Most of them are available on a rental basis and are made of steel or aluminium, which are prone to rust. Pipelines may also be a source of microbial contamination.States to Notify Black Fungus as Epidemic: Who is at High Risk?The country was also facing a shortage of tankers suitable to transport and store oxygen, especially liquid oxygen. As a result, Liquid Nitrogen Gas Tankers were converted to Liquid Oxygen Tankers. Such conversion carries a significant risk of contamination with microbes, including bacteria and fungi, if extreme precaution is not taken.Another factor, Dr Rao pointed out, is the contamination of medical gas, which is the result of compression of 8 cubic feet of atmospheric air into 1 cubic foot of compressed air. All contaminants in atmospheric air, including water and carbon monoxide, are, therefore, concentrated eight-fold in compressed air."Thus, you're sending in compressed eight-fold contaminated air into the patient's major pathways... It becomes very important for us to check the oxygen gas supplies and other gases supplies, especially due to the change in status quo," Dr Rao said.Here’s How to Download COVID-19 Vaccination CertificateDr Ajay Swaroop, ENT Chairman at Delhi’s Sir Ganga Ram Hospital, thinks it’s not a question of oxygen itself, but of storage, the cylinders, the pipes through which the gas is being fed out, and the outlets which might be the source of the fungus.“If it is industrial oxygen, the cylinders are not being treated as medical stores. They are not that clean, they are not sterilised. They may be rusted. They may be lying somewhere in a shed and they may have fungus growing over it. Then, the tubes which are used, they may be contaminated,” Dr Swaroop said.Meanwhile, speaking at the Union Health Ministry press conference, AIIMS Director Dr Randeep Guleria, said there is “no definite link between oxygen therapy and catching the infection”.“Many patients taking treatment at home, who were not on oxygen therapy, have also been found to get infected with mucormycosis," Dr Guleria said.Maha and Now Delhi: Which States Have Halted Vaccines for 18-44?Are There Other Sources of Infection?While the use of industrial oxygen is a major cause of concern, Dr Rao said the mucormycosis wave could also be due to other community factors.“I’m not going to say that one particular factor is responsible. There are plenty of factors that can increase the spore count in the air because we're seeing a wide spectrum of patients," Dr Rao said, adding that it is important to identify all the sources because it not “either-or, it is one upon the other".Steam inhalationAC ventsWaste segregationOxygen concentratorsSteam inhalation introduces water droplets into the air and thus into the nasal passages. These water droplets are capable of carrying fungi."I think anything that is done indiscriminately can be harmful for the body," Dr Rao said.Sonia Gandhi Writes to PM Modi Over Shortage of Black Fungus DrugThe habit of switching off A/C units is a very common practice to save electricity. This may lead to condensation of water and rise in relative humidity and temperature, favouring fungal growth.Decomposition of organic waste due to waste segregation may also act as a source of fungal spores inside the house.While using oxygen concentrators, it's important to use distilled (sterile) water, so that most of the bacteria and viruses are killed. Distilled water does not produce water droplets.Dr Rao also stressed on the need to use hygienic masks to prevent the growth of fungi.How Can We Tackle the Outbreak?At the executive level, it is important for the government to lay down SOPs for the supply chain, along with regular checkups to make sure that sanitisation protocols are followed, especially in gaseous supply chains, Dr Rao said.Postulating and investigating possible sources of mucor at oxygen manufacturing units, hospitals, and at PPE and mask-manufacturing units are also necessary.Dr Swaroop thinks the problem cannot be tackled by trying to enforce with some rule of law.Don’t Call Mucormycosis ‘Black Fungus’: AIIMS Chief“When it comes from within…when people who are in the business of producing oxygen are sort of aware that this can happen…only then the problem will be solved.”Dr Ajay Swaroop, ENT Chairman, Sir Ganga Ram Hospital, DelhiAt the hospital level, the hospitals should up their protocols and be equipped to identify and deal with all sources of contamination, he said.At the community level, it is necessary the people are aware of their responsibilities and how the fungus could be growing at home and in the workplace.Mr Rao said identifying the source is of utmost importance right now, because it is not just one factor causing the epidemic."COVID may come and go, but mucor may remain for long period of time... A slow, gradual, higher baseline of mucor cases."(This was first published on FIT and has been republished with permission.)Get Black Fungus Drug ‘From Wherever in World’: Delhi HC to Centre

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COVID-19: Has Industrial Oxygen Spurred Record Black Fungus Cases?

Doctors and health experts are on a hunt to find out what could be driving the surge in black fungus cases.

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