ADVERTISEMENT

This technique can image over 10,000 genes at once

This technique can image over 10,000 genes at once

Published
Hot News Text
2 min read
This technique can image over 10,000 genes at once
New York, June 10 (IANS) In a new breakthrough research, scientist have found a technique to image more than 10,000 genes at once within individual cells.
The new technique, dubbed intron seqFISH --sequential fluorescence in situ hybridisation--, is a major advance in being able to identify what goes on across the genome in hundreds of different cells at once where previously researchers could only image four to five genes at a time in cells with microscopy.
"Intron seqFISH can help identify cell types and also what the cells are going to do, in addition to giving us a look at the chromosome structure in the same cells," said long Cai from Tianqiao and Chrissy Chen Institute for Neuroscience at California Institute of Technology.
The findings were detailed in the study published in the journal Cell.
In order for genetic instructions to be turned into an actual functioning protein, a process called transcription must first occur which often occurs in pulses, or "bursts".
First, a gene will be read and copied into a precursor messenger RNA, or pre-mRNA, like jotting a quick, rough draft. During the "editing" process, certain regions called introns are cut out of the pre-mRNA.
Using the newly developed intron seqFISH technique, each intron is labelled with a unique fluorescent barcode, enabling it to be seen with a microscope.
These introns then reveals which genes are currently turned on in individual cells, how strongly they are expressed, and where they are located. Because there are 10,421 introns, therefore 10,421 genes can be imaged at once.
Further, because introns stay where the gene is physically located, fluorescently imaging introns allows researchers to visualise where genes are located within the chromosome, the researchers explained.
--IANS
sh/pgh/

(This story was auto-published from a syndicated feed. No part of the story has been edited by The Quint.)

(This story was auto-published from a syndicated feed. No part of the story has been edited by The Quint.)

(The Quint is available on Telegram. For handpicked stories every day, subscribe to us on Telegram)

We'll get through this! Meanwhile, here's all you need to know about the Coronavirus outbreak to keep yourself safe, informed, and updated.

Liked this story? We'll send you more. Subscribe to The Quint's newsletter and get selected stories delivered to your inbox every day. Click to get started.

The Quint is available on Telegram & WhatsApp too, click to join.

ADVERTISEMENT
Stay Updated

Subscribe To Our Daily Newsletter And Get News Delivered Straight To Your Inbox.

Join over 120,000 subscribers!
ADVERTISEMENT