A New Drug Discovery May Halt Spread of Brain Cancer: Study

Scientists have identified a novel drug that could block glioblastoma from spreading.

2 min read
A New Drug Discovery May Halt Spread of Brain Cancer: Study

The Quint DAILY

For impactful stories you just can’t miss

By subscribing you agree to our Privacy Policy

Scientists have identified a novel drug that could block glioblastoma -- one of the deadliest form of brain cancer -- from spreading.

The tissues in our bodies are largely made of fluid. It moves around cells and is essential to normal body function, said researchers from Virginia Polytechnic Institute and State University in the US.

However, in some cases, this fluid may be doing more harm than good, they said.

In glioblastoma, this fluid has a much higher pressure, causing it to move fast and forcing cancer cells to spread. A common cancer therapy, which inserts a drug directly into the tumour with a catheter, can make this fluid move even faster, researchers said.

The study, published in the journal Scientific Reports, may have found a solution to stopping this inevitable cancer cell spread.


The researchers used the drug which they found can block the way cancer cells respond to fluid flow.

They examined the role of interstitial fluid flow in the spread of glioma cells. Interstitial fluid is the fluid that surrounds cells in the body.

In labs, the team used mice with glioblastoma to test how a particular approach to delivering cancer treatment, called convection enhanced delivery, caused glioma cells to invade the rest of the brain.

To block the fluid's rapid movement and the spread of cancer cells, they tested a drug called AMD3100.

The drug, which already has been used in clinics, appeared to be a game changer, said Chase Cornelison, a postdoctoral researcher at Virginia Tech.

This finding could lead to stopping glioblastoma from spreading, said Cornelison, who was earlier with the University of Virginia, where the majority of the research took place.

I am hopeful that since the drug that we used to block flow stimulation is currently used in patients that maybe clinicians, when they do consider using convection enhanced delivery, will combine that with this drug.
Chase Cornelison, a postdoctoral researcher at Virginia Tech

"It (glioblastoma) is so deadly, and there hasn't been a shift in treatment response in decades. Something needs to change," said Jennifer Munson, an assistant professor at Virginia Tech.

(This story was auto-published from a syndicated feed. No part of the story has been edited by The Quint.)

(The Quint is available on Telegram. For handpicked stories every day, subscribe to us on Telegram)

We'll get through this! Meanwhile, here's all you need to know about the Coronavirus outbreak to keep yourself safe, informed, and updated.

Liked this story? We'll send you more. Subscribe to The Quint's newsletter and get selected stories delivered to your inbox every day. Click to get started.

The Quint is available on Telegram & WhatsApp too, click to join.

Read and Breaking News at the Quint, browse for more from fit

Speaking truth to power requires allies like you.
Become a Member

25 10% off


100 10% off


200 10% off

or more


3 months
12 months
12 months
Check Member Benefits
Read More
Stay Updated

Subscribe To Our Daily Newsletter And Get News Delivered Straight To Your Inbox.

Join over 120,000 subscribers!
More News