COVID, Steroids, and AVN: Is COVID Causing Bone Death?
Dr Manish was diagnosed with COVID-19 in September, and went on to suffer from interstitial pneumonia.
Although his symptoms were severe, they lasted a standard 15 days after which he recovered completely.
But, Dr Manish only got a month and a half's respite before the aftermath of his COVID infection started rearing its head.
"After one and a half months, I started having pain in my left hip joint," he says.
After months of persistent pain, Dr Manish was diagnosed with AVN (avascular necrosis), of the hip, stage 2 after months of escalating pain.
Dr Manish, however is not the only one. An increasing number of COVID recovered patients across the country are reporting the rare post-covid complication. There is, however, no official data for this yet.
What is AVN? How is it linked to COVID-19?
FIT speaks to Dr Sanjay Agarwala, Head of Orthopaedics at the P.D. Hinduja National Hospital, Mumbai, who has done extensive research on the subject.
What is Bone Death?
First a quick run down of what AVN (avascular necrosis) is.
Simply put, AVN is the death of bone tissue, that affects the bones of the hip in particular.
"If part of the bone (hip) has a blockage in blood supply, you get pain, and because this bone which is normally hard as wood is no longer hard, it starts collapsing."Dr Sanjay Agarwala, Head of Orthopaedics, P.D. Hinduja National Hospital
AVN, he adds, usually occurs in those between the age group of 15 to 45 and is rare in children. "The only time I've seen AVN in children is when they are suffering from leukemia."
What generally causes AVN?
AVN, Dr Agarwala explains, usually happens because of kinks in the blood vessels in the area. "That part (hip) is more prone to such kinks because of the hairpin bends in the area. These kinks or clotting can lead to bones in that sector dying," he explains.
"The hip bone is also in a weight baring area," he adds. "And when that starts collapsing is when you start getting problems."
COVID-19 and AVN
"During this COVID crisis I got 3 patients of AVN in the months of January to February who were doctors, and I realised that one commonality these three had was that they had had COVID for which steroids have been used."Dr Sanjay Agarwala, Head of Orthopaedics, P.D. Hinduja National Hospital
Whether COVID can directly cause AVN is yet undetermined. But it could be a potential cause, says Dr Agarwala. "In the past year or so we have seen how COVID can impact blood vessel."
On the other hand, "that use of steroids can cause AVN has been established for years," he adds.
The link with Steroid based treatments
Much has been said about steroids and how it can lead to other post COVID complications, including a number of fungal infections that come in every colour of the rainbow–the most notable being black fungus.
"It is lifesaving. I'm not saying you musn't use steroids. But If you have had COVID and have been on steroids, you have a higher propensity to get AVN," Dr Agarwala clarifies.
A study led by Dr Agarwala further points to COVID patients who took smaller doses of steroids also coming back with AVN, and that it generally takes 6 months to year post steroid exposure for AVN to develop.
Treatment for AVN
Depending on the stage of the condition, AVN may require medical support or hip replacement.
Dr Manish was advised by orthopedic surgeons to get surgery done before he connected with Dr Agarwala. "He was confident that stage two, AVN is curable with conservative management, without surgery."
"Dr Agarwala put me on an IV medication and some oral medicines and now after 6 months, my pain has decreased by around 40 percent," adds Dr Manish.
'Early Detection Is the Key'
"In my twenty years of research, what I have realised is that there are medicines that can cure it, control it and reverse it if picked up early enough."Dr Sanjay Agarwala, Orthopedic Surgeon
It can be hard to catch it in the early stages, though, as there are not many early signs or symptoms of AVN, except groin pain and discomfort in the hips.
Moreover, X-rays aren't able to pick up on AVN in the early stages.
"Initially I just thought it was just routine pain so I took painkillers for a week. When the pain didn't calm down, I went to an orthopedic surgeon who advised me to get an X-ray which showed up normal."Dr Manish
This is when Dr Manish's Doctor's instincts kicked in. "I realised this was not just a routine pain. I went back and got an MRI done."
There are 4 stages to the disease.Dr Agarwala explains these as being,
Stage 1 - cannot be detected on X-ray, but can be diagnosed with an MRI scan.
Stage 2 - Can be just about made out on an X-ray, but MRI confirms it. At this stage, according to Dr Agarwala, it is possible to reverse the condition with medication.
Stage 3 - The bone as collapsed and it can be seen on an X-ray.
Stage 4 - You would need a hip replacement.
For this reason, Dr Agarwala advises getting an MRI scan done (and not just an X ray) if you experience persistent groin pain to diagnose it as soon as possible.
"As a doctor I was aware of the rare possibility of COVID causing AVN, but for a normal person, they may not correlate a hip pain or a bone pain to COVID," he added. "They may go unnoticed."
"We think COVID is an illness of the lungs. No body thinks that it could affect our bones and joins also," he adds.
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